简介：Thrombin is the most important and highly targeted protease in coagulation cascade to develop anticoagulation therapy. It has dual function in coagulation system and highly regulated by allosteric mode. Based on binding by various protein and peptides in exosite 1 and 2, it can act as pro-coagulant or anti-coagulant.
简介：Thrombin is the most important and highly targeted protease in coagulation cascade to develop anticoagulation therapy. It has dual function in coagulation system and highly regulated by allosteric mode. Based on binding by various protein and peptides in exosite 1 and 2, it can act as pro-coagulant or anti-coagulant.